When Myotonic Dystrophy is passed from one generation to the next two major patterns are seen

- the symptoms are more severe in the child than the parent
- the age of onset is earlier in the child than the parent

This pattern is called anticipation. This often leads to all three forms of the disease being present in one family. The severity of the disease increases with each generation so that the family may contain a minimally affected grandparent, a classically affected parent and a congenitally affected child.

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Why does the disease increase in severity with successive generations of a family?

> Introduction
> Repeat expansion
> Parental effects
> Quiz